November Road by Lou Berney

Frank Guidry is a gangster, a bad guy who works for bad guys. When he hears something he shouldn't and puts 2 and 2 together when Kennedy is assassinated he realizes he is in trouble and goes on the run. Charlotte is a housewife with two little girls. She is kind and a good mother but she is tired of her life and even more tired of her drunk husband so she packs up the girls and heads out for California.
As fate would have it these two meet and what starts out as a disguise for Guidry turns into something more. Charlotte and the girls make him feel again and that might not be a good thing when you are marked. When Charlotte accepted a ride from the "good Samaritan" Guidry neither one knew how much their lives would change. Wiseguys, good guys and bad guys - this is one cross-country trip of survival and second chances. Perfectly crafted with a blend of quiet wit and charm along with brutal violence, this is a novel that will live in your soul.